The Sestra River (Russian: Сестра́) is a river in Moscow Oblast, Russia. It is a left tributary of the Dubna River (Volga basin). Its source is the Senezh Lake. The length of the river is 138 km (86 mi). The area of its basin is 2,680 km2 (1,030 sq mi). The river freezes up in November - early January and stays under the ice until late March - April. Its main tributary is the Yakhroma River. The town of Klin is located on the Sestra River.